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MULTIPLE SELECT. Select ALL that apply (one or more)
Which of the following are bound to Hb when Hb is in the R state? 2,3 BPG
H+ at the His- (HC3) of β-subunits (which forms an ion pair with Asp94)
Select ALL the TRUE statements regarding antibody (specifically; Immunoglobulin G) structure: The antigen-binding site is located in the Fab portion. The antigen-binding site is formed as a combination of variable domains from one heavy and one light chain. Only the Fab portion has variable domains. Only the Fc portion has constant domains. The Fc portion contains bound carbohydrate. The heavy and light chains are linked by disulfide bonds. The two heavy chains are linked by disulfide bonds. Only the Fc portion has constant domains.
Which of the following describes is/are TRUE statements about polyclonal antibodies? They are synthesized by a population of identical cells. They bind to different antigens with the same epitope. They bind to the same antigen but different epitopes. They are produced by different cells responding to a specific antigen. None of the above statements are TRUE.
Which of the following statements about hemoglobin and myoglobin are TRUE? Free heme groups can bind two molecules of oxygen but heme group Mb will only bind one oxygen molecule. By itself, heme is not a good oxygen carrier. It must be part of a larger protein to prevent oxidation of the Iron atom. Both Hb and Mb are heterotetramers. Both Hb and Mb have proximal histidine and distal histidine near the heme group. Mb and the subunits of Hb have very similar 2nd and 3rd structures but different structures. Mb and Hb carry oxygen from lungs to peripheral tissues.
In what ways do enzymatic catalysts increase the rates of reaction? They decrease the free energy of the reaction. They promote the formation of the transition state. They increase the concentration of reactants. They shift the reaction equilibrium towards the products. They lower the activation energy of the reaction.

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I. Structure of Antibodies – 5 classes of immunoglobulinsAn antibody (formally called immunoglobulin) is a large Y-shaped glycoprotein produced by B-cells and used by the immune system to identify and neutralize pathogens. Antibodies are produced by B cells and are either secreted into circulation or remain expressed on the surface of the B cell.

Structure of AntibodiesThe antibody recognizes a unique part of an antigen. Each tip of the “Y” of an antibody contains a paratope (a structure analogous to a lock) that is specific for one particular epitope (similarly analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can neutralize its target directly or tag it for attack by other parts of the immune system. (Paratopes are like hands on the ends of the Y arms. They bind (grab) their designated epitope, i.e. create a very specific paratope-epitope bond).

Antibodies are glycoproteins belonging to the…


Map: There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single amino acid substitution in a globin polypeptide chain. Some variants produce clinical illness, though not all variants have deleterious effects.

Identify the variant or variants that can be described by each of the three statements at the right by placing the letter corresponding to the statement in the blue outlined rectangle next to the variant:

Statement B may describe more than one variant, and a variant may be described by more than one statement. Some variants will not match any description.

HbS (sickle-cell Hb): substitutes Val for a Glu on the Variant Description surface.

Hb Cowtown: eliminates an ion pair involved in T-state stabilization, pathological symptoms.

Hb Memphis: substitutes one uncharged polar residue for values different from that of HbA on another of similar size on the surface, an isoelectric focusing gel.

Hb Bibba: substitutes a Pro for Leu involved in a…


The correct answers are marked in bold black. Can I know why the option is correct and why the other options are wrong? For each question, write why this option is correct and explain why the other options are wrong. Thanks.

1) Which of the following is the best definition of epitope?A) specific regions on antigens that interact with T-cell receptors (technically T-cell receptors recognize the epitope with MHC)B) specific regions on antigens that interact with MHC class molecules **Most specific, however, I will not expect you to know that much detail this semester**C) specific regions on antigens that interact with haptensD) specific regions on antigens that interact with antibodiesE) specific regions on antigens that interact with perforins

2) CD4 + T cells are activated byA) interaction between CD4 + and MHC II.B) interaction between TCRs and MHC II.C) cytokines released by dendritic cells.D) cytokines released by B cells.E) complement.

3) The antibodies that can bind …


10) An enzyme binds glucose with a dissociation constant (Kd) of 3*10^10 and it binds fructose with a dissociation constant (Kd) of 10^10. a) To which substance does the protein have the higher affinity, glucose or fructose? b) To which substance does the protein bind more strongly? c) How does the protein recognize the substances with which it specifically binds? Explain, including how the two aspects of recognition (or specific binding) affect each other.

11) a) Draw a dipeptide and then redraw it to show the resonance structures for the peptide bond, including arrows to show the movement of electrons. b) What is the effect on the peptide bond in relation to these structures?

12) Explain the metabolic logic of the regulation of Hb activity by CO2. Does CO2 increase or decrease the affinity of Hb for O2? What effect does this have when [CO2] is high? What is the metabolic relationship (MR) of CO2 to Hb? Explain fully what can get high [CO2] to develop and how this is related…


The types of signals that helper T cells provide to follicular B cells that allow the B cells to undergo not only proliferation and differentiation, but also affinity maturation and isotype switching include which of the following?cytokines and CD40LMHC class II and CD28cytokines and CD28MHC class I and CTLA-4Helper T cells stimulate the progeny of B lymphocytes that initially only express certain immunoglobulin molecules to produce antibodies with different isotypes (class) switching.hypervariable regionslight chainsheavy chainscytokine profilesThe function of the spleen is to monitor the blood to help fight infection and to filter out old blood cells. The white pulp in this (or these) organ(s) contains resident DCs that engulf pathogens and present peptides to lymphocytes. The red pulp traps red blood cells that have lost flexibility. These are then engulfed by macrophages.spleenliverthymusbone marrowDefensins and other antimicrobial substances are part of the microbi…


Hello students in this question we are asked what molecule will bind to hemoglobin to form the r state, so the correct option is option b. The answer is oxygen. When oxygen binds the hemoglobin from the relaxed from the constricted state, it takes the relaxed state. That is our state. The next question is about the antigen antibody interaction and its components so for here specifically for eminoglobyling, so the correct options are option: a option b, option c option e option f and option g. So all these options are correct because antigen antibody antigen binding side is located and located in the ephebi region. Antigen binding side is a combination of variable and heavy variable domain from heavy and light chains. That is a correct statement. Only fab portion has variable domain again. This is correct: only the option d is incorrect, so here we have to mark all the possible correct, correct answers, so these options are correct in the next question. In this question we have to write the correct options about polychronal…

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You are watching: SOLVED: MULTIPLE SELECT. Select ALL that apply (one or more) Which of the following are bound to Hb when Hb is in the R state? 2,3 BPG CO2 H+ at the His- (HC3) of β-subunits (which forms an ion pair . Info created by GBee English Center selection and synthesis along with other related topics.