(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments

Abstract

:

1. Introduction

2. Biogenesis and Expression at PMs of GPI-APs

3. Function, Clustering and Endocytosis of GPI-APs

4. Release of GPI-APs

4.1. Cleavage of the GPI Anchor

4.1.1. Transglucosylation of the Glycan Core

4.1.2. Proteolytic Cleavage

4.1.3. Lipolytic Cleavage

4.1.4. Physiological Roles of Proteolytic and Lipolytic Release of GPI-APs

4.2. Release of Full-Length GPI-APs

4.2.1. Release into Exosomes

4.2.2. Release into Microvesicles

4.2.3. Release into Non-Vesicular Structures and Assemblies

Release into LLPs

Release as Protein Oligomers, Multimers and Aggregates

Release for GPI-Binding Proteins

Release into Micelle-Like Complexes

5. Conclusions

Author Contributions

Funding

Institutional Review Board Statement

Informed Consent Statement

Data Availability Statement

Conflicts of Interest

References

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Müller, G.A.; Müller, T.D. (Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments. Biomolecules 2023, 13, 855. https://doi.org/10.3390/biom13050855

Müller GA, Müller TD. (Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments. Biomolecules. 2023; 13(5):855. https://doi.org/10.3390/biom13050855

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Müller, Günter A., and Timo D. Müller. 2023. “(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments” Biomolecules 13, no. 5: 855. https://doi.org/10.3390/biom13050855

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