Week 7 – Biochemistry 500 Fall 21/22

University: Drexel University

Course: Biochemistry (BIO 500)

37 Documents

Students shared 37 documents in this course

3401 Recitation Worksheet Week 7

1.) Where are hemoglobin and the myoglobin located in the body?

2.) Determine which statements apply to hemoglobin, myoglobin, or neither:

a. Oxygen binds irreversibly to this molecule

b. The binding pattern for this molecule is considered to be cooperative

c. This molecule has a greater affinity for oxygen

d. The oxygen dissociation curve is sigmoidal in shape

e. This molecule delivers oxygen more efficiently to tissues

f. The oxygen dissociation curve is hyperbolic in shape

g. Carbon monoxide binds at an allosteric site, lowering oxygen binding


h. As oxygen binds to this molecule the shape of the molecule changes,

enhancing further oxygen binding

3.) After a person spends a day or more at high altitude (with an oxygen partial

pressure of 75 torr), the concentration of 2,3-BPG in that person’s red blood

cells increases. What effect would an increased concentration of 2,3-BPG

have on the oxygen binding curve for hemoglobin? Explain why this

adaptation would be beneficial for functioning well at high altitude.

4.) Which molecules are bound to hemoglobin when hemoglobin is in the R


a. Fe2+

b. 2,3-bisphosphglycerate

c. CO2

d. Fe3+

e. Oxygen

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