Week 7 – Biochemistry 500 Fall 21/22
University: Drexel University
Course: Biochemistry (BIO 500)
37 Documents
Students shared 37 documents in this course
3401 Recitation Worksheet Week 7
1.) Where are hemoglobin and the myoglobin located in the body?
2.) Determine which statements apply to hemoglobin, myoglobin, or neither:
a. Oxygen binds irreversibly to this molecule
b. The binding pattern for this molecule is considered to be cooperative
c. This molecule has a greater affinity for oxygen
d. The oxygen dissociation curve is sigmoidal in shape
e. This molecule delivers oxygen more efficiently to tissues
f. The oxygen dissociation curve is hyperbolic in shape
g. Carbon monoxide binds at an allosteric site, lowering oxygen binding
affinity
h. As oxygen binds to this molecule the shape of the molecule changes,
enhancing further oxygen binding
3.) After a person spends a day or more at high altitude (with an oxygen partial
pressure of 75 torr), the concentration of 2,3-BPG in that person’s red blood
cells increases. What effect would an increased concentration of 2,3-BPG
have on the oxygen binding curve for hemoglobin? Explain why this
adaptation would be beneficial for functioning well at high altitude.
4.) Which molecules are bound to hemoglobin when hemoglobin is in the R
state?
a. Fe2+
b. 2,3-bisphosphglycerate
c. CO2
d. Fe3+
e. Oxygen
